Soldiers - The G.G.G. uses troops of the Wehrmacht in its operations. They wear green field uniforms and bandoliers and possess basic combat training. They use a variety of weapons, ranging from pistols to heavy machineguns, yet are unable to block Rayne's attacks.
Waffen-SS troopers - members of the elite Waffen-SS, these troopers wear panzer-like leather jackets and use the same weapons as regular soldiers. However, they are faster, stronger and can block Rayne's melee attacks as well as use combat knives.
Waffen-SS low-ranking officers (unteroffiziers) - these NCO enemies differ from the regular SS troopers only in that they wear a grey coat. Otherwise, they are almost identical to regular Waffen-SS troopers.
Elite soldier - members of the special forces formed within the G.G.G., under the lead of Kommando, are outfitted with red full body armor for protection against bullets, a face covering gas mask and a steel helmet. They use submachineguns, FG-42s and StG44s and can block Rayne's attacks with ease.
Hazmat troopers - To handle potentially hazardous materials, the G.G.G. outfitted several of their members with haz-mat suits. The air tight suits provided excellent protection against environmental hazards but were ineffective at stopping bullets or Rayne's blades. They possessed basic combat training.
G.G.G. jetpack troopers - equipped with high power jetpacks and air filtering masks, the elite jetpack squads of G.G.G. were deployed during the assault on castle Gaustadt as support units. Their main protection was their mobility, as the heavy protective coats, masks and steel helmets they wore were ineffective against weapons fire or cutting weapons. They usually carried submachineguns or automatic rifles into combat.
Superpanzer Mobile Armor - essentially a bipedal walking tank, these mobile armor were used in the assault on Castle Gaustadt. A squad of five were deployed to secure the castle's Cathedral. The tanks were powered by Diesel engines (as evidenced by the massive exhaust pipes), possessed incredibly heavy armor as well as a minigun, rocket launcher and twin grenade launchers.
Generic enemies: Primarily thugs. Both males and females make up the ranks of the minions (both human and vampire). They are lightly armored and go down with ease. Often armed with either melee weapons (crowbars, axes, swords, guitars, etc.) or guns (pistols, sub-machine guns, shotguns and occasionally tripod-mounted heavy machine guns).
Suicide Bombers: Used by the Kestrels and Slezz to do exactly what their name implies. They have a demolition timer strapped to their chests, which the detonate on getting close to Rayne. Aside from this, they are unarmed.
Ninja: A tricky opponent, the Ninja are the followers of Ephemera. They move very fast, and are able to block Rayne's harpoon attack using their electrified swords. They also attack from a distance by throwing Shuriken. Much like Ephemera, they appear to be dressed in BDSM-style leather.
Foreman: These are large, turned vampires that carry heavy hammers and wear aprons. They are found almost exclusively in industrial areas, notably the large "Wetworks" facility that forms the Shroud-producing tower. What makes them extremely dangerous is that many of their attacks will knock Rayne to the ground, allowing easy follow-up attacks.
Brute: As their name suggests, they have a penchant for brute force and will attack other vampire minions if they get in their way. They have curved horns on their heads resembling those of a ram, which they use when charging head-first at Rayne.
Bio-Armor: Rayne only encounters a handful of these, similar in most respects to Brutes, except that the Bio-Armor are tougher. Although they have no heads, they have no problem finding and attacking their enemies. Xerx's bio-mech suit is a much larger version of the Bio-Armor.
Shadow Legion: A minor threat in most respects. Their speed and agility are daunting, but they are more susceptible to dismemberment than any other minion. The Shadow Legion wear masks with multiple lenses (possibly night vision goggles) and attack with ninja-like moves.
Kagan Elites: Heavily armored and armed with a sword in one hand and a machine gun in the other. They only appear close to the end of the game.
Unraveler: While in actuality a boss in its own right, the Unraveller is given no back story, and seems to be an indiscriminate killer, targeting minions as well as Rayne. It resembles a massive humanoid with long arms and legs, and attacks by spitting acid with enough force to throw enemies off their feet.