Vampires are the central creatures of the BloodRayne series. True to their mythological origins, the vampires portrayed in the games are a breed of nocturnal predators that sustain themselves on the blood of humans. Unlike their mythological counterparts, the vampires of Bloodrayne are not directly depicted as necessarily undead; rather they are living beings that may reproduce among themselves as any other natural creature would. The titular character Rayne is herself half-vampire - a Dhampir. Although they share certain common characteristics as a species, vampires are known to be divided into bloodlines with their own distinct attributes and cultural backgrounds.
- Immortality - Vampires are a biologically immortal species. They are born with immortality, and are eternally young however they are not complete immortals, as severe damage to their bodies can and will kill them.
- Super Strength - As preternatural predators of human blood, all vampires possess some degree of unnatural strength; roughly a dozen times that of a peak human. While not all vampires are equal in terms of strength depending on the strength of their bloodline, even the weakest of vampires is strong enough to physically challenge an imposing human. As such, only the most skilled or physically fit of vampires hunters may suffice to take down a single vampire. The strongest of vampires may single-handedly overturn the cabin section of a semi-truck with relative ease. In hoards, vampires may overcome an entire city.
- Healing Factor - Vampires possess very strong bones and tough skin and are capable of recovering from any projectile wounds, burns or lacerations at an unnatural rate. However, vampires can still be felled by bodily impalement, a massive loss of bodily tissue, the complete obliteration of their body, incineration, decapitation and being exsanguinated. Older/more powerful vampires can recover from torso impalements and are impervious to blades and gunfire—only sunlight and water can ail them.
- Daylight - True to their mythological origins, vampires are burned by the direct touch of sunlight. This process usually results in vampires spontaneously combusting upon exposure; their tissues evaporating and their blood boiling, leaving behind nothing but ash and steam. It has never been revealed if vampires develop some degree of tolerance for sunlight as they age or depending the resilience of their bloodline, but all vampires of all lineages are known to share this lethal photo-sensitivity. Even synthesized ultraviolet light can cause similar effects on them as natural sunlight. As such, ultraviolet weapons may be utilized against them by humans.
- Waters - Water burns their skin like an acid.
- Holy Items - Vampires are unholy creatures and as such, they can't get close to or make contact with holy symbols.
- Physical Trauma - Vampires can be killed by bodily impalement, decapitation, incineration, massive damage or loss of bodily tissue or even the complete obliteration of their body. Additionally, if a vampire is exsanguinated (drained completely of blood) he or she will die.